PROVA

Know everything physically happening to patient tissue in real time, all the time, from microtome to microscope.

Follow S1 to the microscope

Proof for every patient.

Prova S1 lowered into hot water. Its light stays off until the slide senses the heat, then glows as the slide goes under.

Universal compatibility

One slide format. Many workflows.

S1 keeps the footprint of the slides you already run, so it travels the same path through the lab, recording as it goes.

  1. 01

    Label

    Slide printers

    The case label prints on the frosted end. S1's own ID goes with it.

    • Leica IP S
    • Epredia SlideMate AS
    • Epredia SlideMate Laser
    • Primera Signature
    • Sakura Tissue-Tek SmartWrite
    • StatLab PiSmart S1

  2. 02

    Section

    Microtomes, cryostats and cytology prep

    The ribbon is cut here, then floated onto S1. The record starts the moment tissue meets the slide.

    Microtomes

    • Leica HistoCore AUTOCUT
    • Leica HistoCore MULTICUT
    • Epredia HM 355S
    • Sakura Tissue-Tek AutoSection

    Cryostats

    • Leica CM1950
    • Epredia CryoStar NX70
    • Sakura Tissue-Tek Polar

    Cytology slide prep

    • Hologic ThinPrep 5000
    • BD SurePath PrepStain
    • Epredia Cytospin 4

  3. 03

    Float

    Flotation baths

    The section leaves the water on S1, and the slide starts its own record.

    • Leica HistoCore Water Bath M
    • Boekel Deluxe Lighted Tissue Flotation Bath
    • Epredia Digital Paraffin Flotation Bath
    • Leica HI1210

  4. 04

    Dry and bake

    Section dryers and ovens

    Oven and dryer heat, and how long the slide sat in it.

    • CellPath High Capacity Section Dryer
    • CellPath Mini Section Dryer
    • Thermo Scientific Heratherm OGS60

  5. 05

    Stain

    IHC, H&E and special stainers

    Every heated step, timed and temperature-logged. Every run, not every 90 days.

    IHC and ISH

    • Leica BOND-PRIME
    • Leica BOND-III
    • Leica BOND-MAX
    • Roche BenchMark ULTRA PLUS
    • Roche BenchMark GX
    • Agilent Dako Omnis 165 Duo
    • Agilent Dako Autostainer Link 48
    • Sakura Tissue-Tek Genie
    • Biocare ONCORE Pro
    • Biocare intelliPATH+
    • Epredia Lab Vision Autostainer 360
    • Roche VENTANA DISCOVERY ULTRA
    • Biocare intelliPATH FLX

    H&E and routine

    • Roche VENTANA HE 600
    • Leica HistoCore SPECTRA ST
    • Leica HistoCore CHROMAX ST
    • Leica ST5020 Multistainer
    • Sakura Tissue-Tek Prisma Plus
    • Epredia Gemini AS
    • Milestone PRESTO PRO
    • Roche VENTANA Symphony
    • Leica ST5010 Autostainer XL
    • Sakura Tissue-Tek DRS 2000

    Special stains

    • Roche BenchMark Special Stains
    • Agilent Dako Artisan Link Pro

  6. 06

    Coverslip

    Coverslippers

    Handling and motion through mounting, every move counted.

    • Leica HistoCore SPECTRA CV
    • Leica HistoCore CHROMAX CV
    • Leica CV5030
    • Sakura Tissue-Tek Glas g2
    • Sakura Tissue-Tek Film
    • Epredia ClearVue

  7. 07

    Scan

    Whole-slide scanners

    Time to scan, and every bump on the way to the microscope.

    • Leica Aperio GT 450
    • Leica Aperio AT2
    • Roche VENTANA DP 200
    • Roche VENTANA DP 600
    • Hamamatsu NanoZoomer S360
    • Philips IntelliSite SG300
    • 3DHISTECH Pannoramic 1000
    • ZEISS Axioscan 7
    • Epredia E1000 Dx
    • Motic EasyScan Infinity 100
    • Grundium Ocus 40
    • Huron TissueScope iQ

08

Microscope

The pathologist sees the tissue. S1 is built so the record of what it went through arrives with it.

66 instrument examples. Many more exist.One slide format

Instrument names and illustrations show common slide workflows. They are trademarks of their respective owners, and Prova is not affiliated with or endorsed by them. Compatibility is a design goal and requires validation on each instrument.

For V1 labs

You prove the pads every 90 days. What proves the other 89?

V1 shows that each heating pad reached 93 °C and stayed under 99 °C. S1 is built to keep the whole curve for every drawer, so an exception tells you which drawer, when, and by how much.

Prova app concept. S1 is in development; the record shown is illustrative.

ULTRA PLUS heating-pad check

95 °C for 10 minutes, 30 drawers

Read 30 of 30
Drawer 13

Demonstration data

Not a tag. A recorder.

A label tells you which slide it is. S1 is built to tell you what happened to it, logged on the glass itself.

Prova S1 opened to show its circuit board, lifting a paraffin section from a water bath
Concept render
Temperature
Multi-point history, logged on the slide.
Handling
Every move, from microtome to microscope.
Identity
Linked to the instrument and the run.
Memory
Append-only. Read with any NFC phone.

Prova app

Read it with your phone.

Hold any NFC phone to S1. The Prova app shows what the slide went through, step by step, and flags anything outside your limits.

9:41Prova

Hold to read

Bring the top of your phone to the slide.

Reading S1 · 0x7A3F-21C9

Cancel
01Tap to readNo reader, no cable, nothing to install on your network.
9:41Within limits

S1 · 0x7A3F-21C9

Case S26-04417 · Block A3 · Slide 2

  • Float45.1 °C · 38 s
  • Dry59.8 °C · 30 min
  • StainRun 1182
  • Scan6 bumps
View full record
02See the whole pathTemperature, time and handling for every step the slide took.
9:411 exception

Dry ran hot

S1 · 0x7A3F-22D0 · Oven 2

Above limit41 min
Peak68.2 °C
Started2:14 PM
Flag for review
03Know which slide, when, and by how muchAn exception names the step and the size of the miss, so you act on that slide, not the whole run.
9:41Record

Prova Record

Append-only. Written on the slide as it happened.

Events1,204
Steps6
Read byHistology · Bench 3
IntegrityVerified

sha256 9f2c 41e7 b0d3 77a1 5c9e 0b44 e2f8 1d6a

Share PDF
04Share the proofA record that travels with the slide, for your QA file or the pathologist.

Prova app concept. S1 is in development; screens and values are illustrative.

A standard slide that keeps its own record.

Prova S1 face-on: its circuit board in the top third, glass below
  • 75 × 25 mm. The footprint of the slides you already run.
  • Drop-in. Built for existing racks, stainers and scanners.
  • Any phone. Tap to read with the Prova app.
  • No IT project. Nothing to install on your network.

Planned capabilities. Initial scope: blank and control slides. Performance and instrument compatibility require validation.

Prova S1 packaging from above: a plum sleeve marked PROVA S1, slid open to show the slides in their tray

Your S1 demo kit is on us.

Order V1 and we'll send your lab a complimentary Prova S1 demo kit as S1 becomes available. One kit per lab.

Order V1